Vaccine efficacy studies with Nobivac® Bb for cats

Two trials have been carried out to determine the efficacy and onset of immunity of Nobivac® Bb for cats. These studies show that Nobivac® Bb for cats can be given to kittens as young as 4 weeks and that significant protection is obtained as early as 72 hours after vaccination.

Efficacy of vaccination

In the first study (Williams et al 2002) 4 week old kittens were vaccinated with Nobivac® Bb for cats by the intranasal route. Three weeks later the vaccinated kittens and a number of unvaccinated controls were challenged with an aerosol of virulent Bordetella bronchiseptica. Vaccination reduced the development of clinical sign scores associated with respiratory tract infection by 92% as compared to unvaccinated controls. 		clinical scores for Bordetella bronchiseptica vaccination with Nobivac Bb for cats
Mean clinical scores of control and vaccinated cats following challenge 3 weeks post-vaccination

Onset of immunity

In this study (Williams et al 2002, Gray et al 2002a), 8 week old kittens were vaccinated with Nobivac® Bb for cats by the intranasal route. The vaccinated kittens were challenged with virulent Bordetella bronchiseptica 72 hours after vaccination. Mean clinical score in vaccinated cats was reduced 79% compared to the control cats. 		clinical scores for Bordetella bronchiseptica vaccination with Nobivac Bb for cats
Mean clinical scores of control and vaccinated cats following challenge 72 hours post vaccination
backNobivac Bb duration of immunity studiesNobivac Bb safety studiesNobivac Bb summary of product characterisitics